Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein |
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Authors: | Aoyagi Mika Zhai Dayong Jin Chaofang Aleshin Alexander E Stec Boguslaw Reed John C Liddington Robert C |
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Affiliation: | Burnham Institute for Medical Research, La Jolla, CA 92037, USA. |
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Abstract: | Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses. |
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Keywords: | poxvirus vaccinia virus virulence crystal structure Bcl-2 apoptosis |
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