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Frontal distribution of early cortical somatosensory evoked potentials to median nerve stimulation
Affiliation:1. Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, UK;2. Hokuto Hospital MEG Lab, Hokkaido, Japan;3. S4S (UK) Limited & Smilelign Ltd, 151 Rutland Road, Sheffield S3 9PT, UK;4. Engineering Faculty, Universidad de Antioquia UDEA, calle 70 No 52-21, Medellín, Colombia;5. Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK;6. QuSpin Inc., 2011 Cherry Street, Unit 112, Louisville, CO 80027, USA;7. Institute of Cognitive Neuroscience, University College London, 17-19 Queen Square, London WC1N 3AZ, UK;1. 2;2. Department of Translational Neuroimaging, H.U.B. – Hôpital Erasme, Brussels, Belgium
Abstract:The topography of early frontal SEPs (P20 and N26) to left median nerve stimulation was studied in 30 normal subjects and 3 patients with the left frontal bone defect. The amplitudes of P20 and N26 were maximum at the frontal electrode (F4) contralateral to the stimulation and markedly decreased at frontal electrodes ipsilateral to the site of stimulation. There was, however, no latency difference of P20 and N26 between ipsilateral and contralateral frontal electrodes. These results suggest that the origin of the ipsilateral and contralateral P20 and N26 is the same. The wide distribution of P20 and N26 over both frontal areas could be explained by assuming a smearing effect from generators actually located in the rolandic fissure and motor cortex.
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