SIR2 calls upon the ER |
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Authors: | Tatar Marc |
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Affiliation: | Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA. |
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Abstract: | Resveratrol induces longevity in C. elegans through the action of SIR2. Recently published work shows that resveratrol induces genes of the unfolded protein stress response of the endoplasmic reticulum. Paradoxically, these stress genes are repressed by SIR2, suggesting that resveratrol increases life span by inhibiting this SIR2 action. |
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