Persistence of duplicated PAC1 receptors in the teleost, Sparus auratus |
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| Authors: | João CR Cardoso Edwin CJM de Vet Bruno Louro Greg Elgar Melody S Clark Deborah M Power |
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| Affiliation: | (1) CCMAR, Molecular and Comparative Endocrinology, University of Algarve, 8005-139, Faro, Portugal;(2) Laboratory of Molecular Signalling, The Babraham Institute, CB2 4AT Cambridge, UK;(3) School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, E1 4NS London, UK;(4) British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge, CB3 0ET Cambridge, UK |
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| Abstract: | Background: Duplicated genes are common in vertebrate genomes. Their persistence is assumed to be either a consequence of gain of novel function (neofunctionalisation) or partitioning of the function of the ancestral molecule (sub-functionalisation). Surprisingly few studies have evaluated the extent of such modifications despite the numerous duplicated receptor and ligand genes identified in vertebrate genomes to date. In order to study the importance of function in the maintenance of duplicated genes, sea bream (Sparus auratus) PAC1 receptors, sequence homologues of the mammalian receptor specific for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide), were studied. These receptors belong to family 2 GPCRs and most of their members are duplicated in teleosts although the reason why both persist in the genome is unknown. |
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