| 天麻酯溶性酚性成分对大鼠脑缺血/再灌注损伤的保护作用 |
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| 引用本文： | 李秀芳,孙衍鲲,张维明,段小花,代蓉,林青.天麻酯溶性酚性成分对大鼠脑缺血/再灌注损伤的保护作用[J].天然产物研究与开发,2011,23(5):842-845,852. |
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| 作者姓名： | 李秀芳 孙衍鲲 张维明 段小花 代蓉 林青 |
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| 作者单位： | 1. 云南中医学院药理教研室,昆明,650500
2. 云南农业大学农学与生物技术学院,昆明,650201 |
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| 基金项目： | 国家自然科学基金项目(30760305); 云南省应用基础研究计划面上项目(2007C076M) |
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| 摘 要： | 为探讨天麻酯溶性酚性成分对大鼠脑缺血/再灌注的保护作用,本实验采用线栓法复制了大鼠局灶性脑缺血再灌注损伤模型,以神经学评分、脑梗塞体积、脑组织内水分含量、脑组织内钙调蛋白依赖性蛋白激酶(CaMKⅡ)表达作为评价指标,考察天麻酯溶性酚性成分的作用,结果表明天麻酯溶性酚性成分能够明显改善模型动物的神经病学症状,缩小脑梗塞体积,减轻脑水肿,调节CaMKⅡ的表达水平。说明天麻酯溶性酚性成分在防治大鼠脑缺血/再灌注损伤方面具有明显作用。
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| 关 键 词： | 天麻 酯溶性酚性成分 脑缺血/再灌注 |
Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Iniury |
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| LI Xiu-fang,SUN Yan-kun,ZHANG Wei-ming,DUAN Xiao-hua,DAI Rong,LIN Qing.Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Iniury[J].Natural Product Research and Development,2011,23(5):842-845,852. |
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| Authors: | LI Xiu-fang SUN Yan-kun ZHANG Wei-ming DUAN Xiao-hua DAI Rong LIN Qing |
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| Institution: | LI Xiu-fang1,SUN Yan-kun1,ZHANG Wei-ming2,DUAN Xiao-hua1,DAI Rong1,LIN Qing1 1Yunnan University of Traditional Chinese Medicine,Kunming 650500,China,2Yunnan Agricultural University,Kunming 650201 |
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| Abstract: | The main aim was to investigate the protective effect of esterified phenolic compounds from Gastrodia elata Blume.on cerebral ischemia-reperfusion injury.The middle cerebral artery occlusion(MCAO) model was used.The neurological score,infarct volume,brain tissue water content,and brain tissue Calmodulin-dependent proteinkinase Ⅱ(CaMKⅡ) expression were evaluated.The results showed that esterified phenolic compounds of G.elata could significantly improve the neurological symptoms,reduce infarct volume and cerebral edema,regulate the expression of CaMKⅡ.Esterified phenolic compounds of G.elata had a significant protective effect on cerebral ischemia-reperfusion injury. |
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| Keywords: | Gastrodia elata Blume ethyl acetate extract cerebral ischemia-reperfusion |
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