| 壳聚糖微球分散体系的抑菌性研究 |
| |
| 引用本文： | 任丽宏,陈西广,程晓杰,周旋,孔明. 壳聚糖微球分散体系的抑菌性研究[J]. 天然产物研究与开发, 2011, 23(5): 828-832 |
| |
| 作者姓名： | 任丽宏 陈西广 程晓杰 周旋 孔明 |
| |
| 作者单位： | 中国海洋大学海洋生命学院,青岛,266003 |
| |
| 基金项目： | 国家自然科学基金资助项目(NSFC 81071274) |
| |
| 摘 要： | 以乳化交联法制备的壳聚糖微米微球(CMs)为试验材料,研究其对金黄色葡萄球菌和大肠杆菌的抑菌行为,并对其浓度因素、粒径因素和抑菌机理做了探讨。结果表明CMs的抑菌作用随其浓度的增加和粒径的减小而增强。在浓度<0.7 mg/mL时,CMs对细菌的生长具有先抑制后促进的作用;当浓度≥0.7 mg/mL时对细菌有杀灭作用。CMs对两种细菌的最小抑菌浓度和最小杀菌浓度分别为0.8、1.4 mg/mL和1.0、1.8 mg/mL,表明壳聚糖微球对金黄色葡萄球菌和大肠杆菌均具有明显的抑制作用,且金黄色葡萄球菌对微球抑制作用的反应比大肠杆菌更敏感。扫描电子显微镜观察发现,细菌能迅速贴附在CMs表面,并且贴壁后的细菌发生了明显的形态变化,有的甚至完全被破坏。
|
| 关 键 词： | 壳聚糖微球 乳化交联法 抑菌活性 |
Antibacterial Activities of Chitosan Microspheres |
| |
| REN Li-hong,CHEN Xi-guang,CHENG Xiao-jie,ZHOU Xuan,KONG Ming. Antibacterial Activities of Chitosan Microspheres[J]. Natural Product Research and Development, 2011, 23(5): 828-832 |
| |
| Authors: | REN Li-hong CHEN Xi-guang CHENG Xiao-jie ZHOU Xuan KONG Ming |
| |
| Affiliation: | REN Li-hong,CHEN Xi-guang,CHENG Xiao-jie,ZHOU Xuan,KONG Ming College of Marine Life Sciences,Ocean University of China,Qing dao 266003,China |
| |
| Abstract: | The chitosan microspheres(CMs) were prepared via emulsion chemical cross-linking method.The antibacterial activities of CMs with different concentrations and different diameters against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25992 were investigated,and the inhibition mechanisms were also discussed.The results indicated that the antibacterial activities increased with the increasing of concentration and the decreasing of diameter of CMs.The CMs could inhibit the growth of the bacteria in ... |
| |
| Keywords: | chitosan microspheres emulsion chemical cross-linking method antibacterial activities |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
