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| 海洋真菌Xylaria sp.SOF11中细胞松弛素类化合物的研究 | |
| 引用本文： | 陈子明,汪中文,黄洪波,陈玉婵,章卫民,张长生,鞠建华. 海洋真菌Xylaria sp.SOF11中细胞松弛素类化合物的研究[J]. 天然产物研究与开发, 2011, 23(5): 801-804 |
| 作者姓名： | 陈子明 汪中文 黄洪波 陈玉婵 章卫民 张长生 鞠建华 |
| 作者单位： | 1. 中国科学院海洋生物资源可持续利用重点实验室;中国科学院海洋微生物中心;广东省海洋药物重点实验室;中国科学院南海海洋研究所,广州510301;中国科学院研究生院,北京100049 2. 中国科学院海洋生物资源可持续利用重点实验室;中国科学院海洋微生物中心;广东省海洋药物重点实验室;中国科学院南海海洋研究所,广州510301 3. 广东省微生物研究所,广州,510070 |
| 基金项目： | 中国科学院知识创新工程重要方向项目(KSCX2-YW-G-065,KZCX2-YW-JC202,KZCX2-EW-G-12); 广东省科技计划项目(2010B030600010); 中国科学院南海海洋所领域前沿项目(LYQY200805) |
| 摘 要： | 从海洋真菌Xylaria sp.SOF11的液体发酵提取物中分离到3个化合物,通过1H及13C NMR,2D NMR等方法,分别鉴定为19,20-epoxycytochalasin Q(1)、18-deoxy-19,20-epoxycytochalasin Q(2)和19,20-epoxycytochala-sin C(3)。化合物1～3对两株肿瘤细胞MCF-7和NCI-H460显示较弱的细胞毒活性。 |
| 关 键 词： | 海洋真菌 炭角菌属 次级代谢产物 细胞松弛素 |
Cytochalasins from Marine-derived Fungus Xylaria sp.SOF11 |
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| CHEN Zi-ming,WANG Zhong-wen,HUANG Hong-bo,CHEN Yu-chan,ZHANG Wei-min,ZHANG Chang-sheng,JU Jian-hua. Cytochalasins from Marine-derived Fungus Xylaria sp.SOF11[J]. Natural Product Research and Development, 2011, 23(5): 801-804 | |
| Authors: | CHEN Zi-ming WANG Zhong-wen HUANG Hong-bo CHEN Yu-chan ZHANG Wei-min ZHANG Chang-sheng JU Jian-hua |
| Affiliation: | CHEN Zi-ming1,2,WANG Zhong-wen1,HUANG Hong-bo1,CHEN Yu-chan3,ZHANG Wei-min3,ZHANG Chang-sheng1,JU Jian-hua1 1 The Chinese Academy of Sciences Key Laboratory of Marine Bio-resourses Sustainable Utilization,RNAM Center for Marine Microbiology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Guangzhou 510301,China,2 Graduate University of the Chinese Academy of Sciences,Beijing 100049,3 Guangdong Institute of Microbiology,Guangzhou 510070 |
| Abstract: | Three cytochalasins were obtained from the fermentation broth of the marine-derived fungus Xylaria sp.SOF11,which was isolated from marine sediment collected from the South China Sea.On the basis of 1 H,13 C and 2D NMR spectral data,these compounds 1-3 were identified as 19,20-epoxycytochalasin Q(1),18-deoxy-19,20-epoxycytochalasin Q(2) and 19,20-epoxycytochalasin C(3).Compounds 1-3 showed weak cytotoxicities against two tumor cell lines MCF-7 and NCI-H460 in a MTT assay. |
| Keywords: | marine-derived fungus Xylaria sp.SOF11 secondary metabolite cytochalasin |
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