| 链霉菌FIM 95-F1产生的抗真菌抗生素S1 |
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| 引用本文： | 彭飞,谢阳,陈路劼,江红,连云阳. 链霉菌FIM 95-F1产生的抗真菌抗生素S1[J]. 天然产物研究与开发, 2011, 23(5): 809-814 |
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| 作者姓名： | 彭飞 谢阳 陈路劼 江红 连云阳 |
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| 作者单位： | 福建省微生物研究所福建省新药(微生物)筛选重点实验室,福州,350007 |
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| 基金项目： | 福建省自然科学基金(2009J01077); 国家重大专项“重大新药创新”药物筛选及相关技术平台(2009ZX9302-004;010ZX09401-403) |
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| 摘 要： | 放线菌FIM 95-F1的形态特征、培养特性及生理生化特征和16S rDNA序列分析表明该菌属于Strepto-myces castelarensis的一个变种,暂定名为S.castelarensis FIM 95-F1。本研究利用高速逆流色谱分离和结晶法相结合的方法从放线菌FIM 95-F1胞内分离纯化抗真菌抗生素S1。化合物理化性质和UV、IR、MS以及NMR等波谱分析结果表明化合物S1与抗真菌抗生素Scopafungin同质,为36元环大环内酯类抗生素。S1对白色念珠菌(Candida albicans)、黑曲霉(Aspergillus niger)及红酵母(Rhodotorula sp.)均有抗菌活性,其MIC分别为0.234、0.469μg/mL和0.234μg/mL。
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| 关 键 词： | Streptomyces castelarensis 分离纯化 结构 scopafungin |
Antifungal Antibiotic S1 Produced by Streptomyces castelarensis FIM95-F1 |
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| PENG Fei,XIE Yang,CHEN Lu-jie,JIANG Hong,LIAN Yun-yang. Antifungal Antibiotic S1 Produced by Streptomyces castelarensis FIM95-F1[J]. Natural Product Research and Development, 2011, 23(5): 809-814 |
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| Authors: | PENG Fei XIE Yang CHEN Lu-jie JIANG Hong LIAN Yun-yang |
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| Affiliation: | PENG Fei,XIE Yang,CHEN Lu-jie,JIANG Hong,LIAN Yun-yang Fujian key laboratory of Screening for Novel Microbial Products,Fujian Instutite of Microbiology,Fuzhou 350007 |
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| Abstract: | Based on the taxonomic study,the antifungal antibiotic S1 producer FIM95-F1 was named as Streptomyces castelarensis FIM 95-F1 tentatively.The bioactive metabolite S1 was isolated and purified from the mycelia of strain FIM 95-F1 using high speed countercurrent chromatography(HSCCC) and crystallization methods.Basic physico-chemical properties and UV,IR,MS,and NMR spectra data suggested that antibiotic S1 was identical with Scopafungin,a 36membered ring macrolide antibiotic.Antibiotic S1 showed potent antifu... |
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| Keywords: | Streptomyces castelarensis isolation and purification structure scopafungin |
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