| 槲皮素在介孔分子筛孔道中的组装与缓释研究 |
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| 引用本文： | 李华,高天宇,卢婧,吴辉,王文蜀.槲皮素在介孔分子筛孔道中的组装与缓释研究[J].天然产物研究与开发,2011,23(5):909-912. |
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| 作者姓名： | 李华 高天宇 卢婧 吴辉 王文蜀 |
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| 作者单位： | 中央民族大学生命与环境科学学院,北京,100081 |
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| 基金项目： | 中央民族大学高等学校111学科创新引智计划(B08044);中央民族大学985工程(CUN985-03-03) |
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| 摘 要： | 采用后组装法将非水溶性的治疗冠心病药物槲皮素组装进入MCM-41介孔分子筛的孔道中,药物组装率达37%m(药物)/m(药物总量)],用XRD,扫描电镜和IR对药物组装体进行了表征;通过测定组装体在体外模拟人工小肠液中的溶出速率,表明制得了槲皮素/MCM-41缓释体系。
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| 关 键 词： | MCM-41 槲皮素 组装 缓释 |
Assembling and Sustained-release of Quercetin Encapsulated in Mesoporoas Molecular Sieve |
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| LI Hua,GAO Tian-yu,LU Jing,WU Hui,WANG Wen-shu.Assembling and Sustained-release of Quercetin Encapsulated in Mesoporoas Molecular Sieve[J].Natural Product Research and Development,2011,23(5):909-912. |
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| Authors: | LI Hua GAO Tian-yu LU Jing WU Hui WANG Wen-shu |
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| Institution: | LI Hua,GAO Tian-yu,LU Jing,WU Hui,WANG Wen-shu Life and Environment Science College,Minzu University of China,beijing 100081,China |
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| Abstract: | Using ethanol solution method to assemble non-water-soluble drug for coronary heart disease quercetin into the pores of MCM-41,drug-assembling rate reached 37% m(drug)/m(total drug)].The characterization of quercetin-MCM-41 was analyzed by XRD,SEM and IR techniques,and the release rate of the assemblies was measured in the artificial intestinal fluid.The results indicated that quercetin/MCM-41 sustained-release system was established. |
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| Keywords: | MCM-41 quercetin assembing sustained-release |
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