Specific binding sites for 5-hydroxytryptamine on rat blood platelets. |
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Authors: | A H Drummond and J L Gordon |
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Abstract: | 5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4 degrees C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor. |
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