The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs. |
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| Authors: | Ryozo Kamimura Naoki Miura Syusaku Suzuki |
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| Institution: | Division of Laboratory Animal Science, Research Center for Life Science Resources, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan. |
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| Abstract: | Acute myocardial ischemia was induced by occluding the LAD in Clawn miniature pigs. Eight pigs (group 1) were subjected to 6 h ischemia and nine pigs (group 2) were subjected to 20 min ischemia, followed by reperfusion for 340 min. Three animals of the group 1 died due to ventricular fibrillation after occlusion and in group 2, four animals died due to the arrhythmia after reperfusion. Though the ischemic area of group 2 (15.6% of the ventricle) was narrower than that of group 1 (21.7%), the survival rate was lower. We supposed that ischemia-reperfusion injuries were strongly connected with the hemodynamics of group 2. Clawn miniature pigs are useful experimental animals for myocardial ischemic researches. |
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