Endothelin Receptors in Rat Pituitary Gland |
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| Authors: | Shigeki Shibata Akihiko Himeno Kazuto Shigematsu Keisuke Tsutsumi Yasuko Sakurai-Yamashita Kimihiro Yamashita |
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| Affiliation: | (1) Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852, Japan;(2) Department of Pharmacology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852, Japan;(3) Department of Pathology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852, Japan;(4) Department of Neurosurgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852, Japan |
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| Abstract: | 1. We used the quantitative receptor autoradiographic method plus 125I-endothelin-1 (125I-ET-1), BQ-123, a specific antagonist for the endothelin ETA receptor, and sarafotoxin S6c, a selective agonist for the ETB receptor to investigate the ET receptor in the rat pituitary gland.2. The method revealed that the BQ-123-sensitive ETA receptor was present predominantly in the anterior lobe and Rathke's pouch.3. The posterior lobe contained BQ-123-sensitive ETA and sarafotoxin S6c-sensitive ETB receptors, in almost the same proportion. There was no significant 125I-ET-1 binding to the intermediate lobe.4. Knowledge of the heterogeneous distribution of ET receptor subtypes in the pituitary gland supplies information that will be pertinent to physiological investigations of the gland. |
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| Keywords: | endothelin ETA receptor ETB receptor rat pituitary gland Rathke's pouch BQ-123 sarafotoxin S6c quantitative receptor autoradiography |
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