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Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex |
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| Authors: | Mei-Jin Li Tao-Yu Lan Zhi-Shan Lin Changqing Yi Guo-Nan Chen |
| Affiliation: | 1. Key Laboratory of Analysis and Detection Technology for Food Safety (Ministry of Education and Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, People’s Republic of China 3. Beijing Synchrotron Radiation Laboratory, Institute of High Energy Physics, The Chinese Academy of Sciences, Beijing, 100039, China 2. School of Engineering, Sun Yat-Sen University, Guangzhou, 510275, People’s Republic of China |
| Abstract: | A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV–vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects. |
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