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| 环磷酰胺诱导小鼠血小板减少症模型的建立(英文) | |
| 引用本文： | 聂红,李孔燕,张晓琦,冯雪莹,杨端容,吴玉斯,周玖瑶,叶文才.环磷酰胺诱导小鼠血小板减少症模型的建立(英文)[J].动物学研究,2009,30(6). |
| 作者姓名： | 聂红 李孔燕 张晓琦 冯雪莹 杨端容 吴玉斯 周玖瑶 叶文才 |
| 作者单位： | 1. 暨南大学,药学院,广州,510632;暨南大学,中药药效物质基础及创新药物研究广东省高校重点实验室,广州,510632 2. 暨南大学,中药药效物质基础及创新药物研究广东省高校重点实验室,广州,510632;暨南大学,药学院中药及天然药物研究所,广州,510632 3. 暨南大学,国际学院,广州,510632 4. 暨南大学,药学院,广州,510632 5. 广州中医药大学,广州,510006 |
| 基金项目： | the 211 Project of Jinan University，the Team Project of Natural Science Foundation of Guangdong Province，the Popular Science Foundation of Science & TechnoIogy Bureau of Guangzhou City，the Natural Science Foundation of Guangdong Province，the Jinan University Natural Science Foundation，the Science and Technology Innovation Project for Undergraduates |
| 摘 要： | 比较由环磷酰胺两种不同给药方式诱导小鼠血小板减少症模型的效果,并对效果较稳定的一种给药方式进行最佳造模剂量摸索,以期确定一个造模效果较好,毒副作用较低,利于观察治疗药物疗效的血小板减少症模型.模型A组,第1天尾静脉注射环磷酰胺200 mg/kg,然后连续6 d,每天1次以维持剂量30 mg/kg腹腔注射环磷酰胺.模型B组,按150 mg/kg皮下注射环磷酰胺,每天1次,连续3 d.结果显示模型B组造模效果较好,故以模型B组给药方法进行剂量摸索实验.由第7天的血小板计数可知环磷酰胺低(100 mg/kg)、中(120mg/kg)、高(140 mg/kg)剂量均可引起血小板减少症,而低剂量组与其他组比较有高效低毒的特点,更有利于观察治疗药物的作用,可用于具有升血小板作用药物的药效学研究. |
| 关 键 词： | 血小板减少症 环磷酰胺 模型 |
Establishment of a Mouse Thrombocytopenia Model Induced by Cyclophosphamide |
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| NIE Hong,LI Kong-yan,ZHANG Xiao-qi,FENG Xue-ying,YANG Duan-rong,WU Yu-si,ZHOU Jiu-yao,YE Wen-cai.Establishment of a Mouse Thrombocytopenia Model Induced by Cyclophosphamide[J].Zoological Research,2009,30(6). | |
| Authors: | NIE Hong LI Kong-yan ZHANG Xiao-qi FENG Xue-ying YANG Duan-rong WU Yu-si ZHOU Jiu-yao YE Wen-cai |
| Institution: | NIE Hong1,2,LI Kong-yan1,ZHANG Xiao-qi2,3,FENG Xue-ying4,YANG Duan-rong4,WU Yu-si1,ZHOU Jiu-yao5,YE Wen-cai2,3 (1. College of Pharmacy,Jinan University,Guangzhou 510632,P.R. China,2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,3. Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,4. International School,Guangzhou 5... |
| Abstract: | An experiment was conducted to compare the effects of two mouse thrombocytopenia models induced by cyclophosphamide at two different administration routes to determine a proper cyclophosphamide administration route that could cause stable thrombocytopenia. A suitable drug dosage that could induce thrombocytopenia in mouse efficiently with the definite administration route was then investigated. BALB/c mice were randomly divided into Normal,Model A and Model B groups. To Model A,200 mg/kg of cyclophosphamide... |
| Keywords: | Thrombocytopenia Cyclophosphamide Model |
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