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DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice |
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| Authors: | Martine de Boer,Maaike te Lintel Hekkert,Jiang Chang,Bibi S. van Thiel,Leonie Martens,Maxime M. Bos,Marion G. J. de Kleijnen,Yanto Ridwan,Yanti Octavia,Elza D. van Deel,Lau A. Blonden,Renata M. C. Brandt,Sander Barnhoorn,Paula K. Bautista-Niño,Ilona Krabbendam-Peters,Rianne Wolswinkel,Banafsheh Arshi,Mohsen Ghanbari,Christian Kupatt,Leon J. de Windt,A. H. Jan Danser,Ingrid van der Pluijm,Carol Ann Remme,Monika Stoll,Joris Pothof,Anton J. M. Roks,Maryam Kavousi,Jeroen Essers,Jolanda van der Velden,Jan H. J. Hoeijmakers,Dirk J. Duncker |
| Affiliation: | 1. Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands;2. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands;3. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands;4. Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany;5. Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands;6. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands Department of Radiotherapy, Erasmus MC, Rotterdam, The Netherlands;7. Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;8. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands Centro de Investigaciones, Fundación Cardiovascular de Colombia- FCV, Bucaramanga, Colombia;9. Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;10. I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, Technical University of Munich, Munich, Germany DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany Walter-Brendel-Centre for Experimental Medicine, Ludwig Maximilian University of Munich, Munich, Germany;11. Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands;12. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands;13. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands;14. Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;15. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands Department of Radiotherapy, Erasmus MC, Rotterdam, The Netherlands;16. Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands Netherlands Heart Institute, Utrecht, The Netherlands;17. Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands CECAD Forschungszentrum, Universität zu Köln, Köln, Germany Princess Máxima Center for Pediatric Oncology, Genome Instability and Nutrition, ONCODE Institute, Utrecht, The Netherlands |
| Abstract: | |
| Keywords: | apoptosis cardiac function congestive heart failure DNA damage DNA repair |