Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters An evaluation of 24 compounds |
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| Affiliation: | 1. Department of Environmental Health Sciences, Yale School of Public Health, 60 College St., New Haven, CT 06510, United States;2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 9609 Medical Center Dr, Rockville, MD 20850, United States;3. Emeritus Professor Department of Environmental Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO 80523-1691, United States;4. JRN-Environmental Health Sciences, Ltd, 10916 Wickshire Way, North Bethesda, MD 20852, United States;5. Department of Environmental and Occupational Health, Dornsife School of Public Health at Drexel University, 3215 Market St, Philadelphia, PA 19104, United States;6. TNO, Zeist, The Netherlands;7. Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX, 78238-5166, United States |
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| Abstract: | Chemically-induced sister-chromatid exchange (SCE) was measured in vivo in bone marrow of Chinese hamsters. Chemicals were administered either intraperitoneally or orally and increased SCE frequencies were noted with 6 of 6 direct-acting genotoxins and with 9 of 14 activation-dependent genotoxins. Metronidazole, O-toluidine, 4-nitro-O-phenylenediamine and 2-nitro-p-phenylenediamine, compounds which have shown either mutagenic or carcinogenic activity, did not induce SCE in vivo. 4 non-genotoxins and 4 different control treatments did not induce SCE. The results show that the in vivo SCE method may be useful for the identification of genotoxins and that the outcome of the test is, for certain chemicals, dependent upon the route of exposure. |
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