Benz[j]aceanthrylene: A novel polycyclic aromatic hydrocarbon with bacterial mutagenic activity |
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| Affiliation: | 1. Department of Mechanical Engineering, Faculty of Engineering, University of Kufa, Najaf, Iraq;2. Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, University of Manchester, Manchester, M13 9PL, UK;1. Joint Institute for High Temperatures RAS, Izhorskaya 13 Bld. 2, Moscow 125412, Russia;2. Bauman Moscow State Technical University, 2nd Baumanskaya Street 5, Moscow 105005, Russia;1. Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan;2. Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan;3. Center for Emergent Functional Matter Science, National Chiao Tung University, Hsinchu; Institute of Atomic and Molecular Sciences, Taipei, Taiwan |
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| Abstract: | Initial studies on the mutagenicity and metabolism of a novel cyclopenta-PAH, benzj]aceanthrylene, are reported in the Salmonella bacterial system. The spectrum of activity of benzj]aceanthrylene over the 5 Ames tester strains is similar to that of benzoa]pyrene, and the dose-response curves for strain TA98 are comparable. Like other biologically active PAH, benzj]aceanthrylene is a frame-shift mutagen requiring metabolic activation. An interesting feature of the S9 dependence of activity is the low concentration (≅10-fold smaller than for benzoa]pyrene) at which optimal activity is observed. The 1,2-dihydro-1,2-diol (product of metabolism of the cyclopenta-ring) appears to be the predominant metabolite, and implicates the 1,2-oxide as the ultimate mutagenic species. |
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