Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed Streptococcus thermophilus MN-ZLW-002 |
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| Authors: | Yating Luo Ruyue Cheng Huijing Liang Zhonghua Miao Jiani Wang Qingqing Zhou Jianguo Chen Fang He Xi Shen |
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| Affiliation: | 1)Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.16, 3rd Section, South Renmin Road, 610041, Chengdu, Sichuan, China;2)R&D Center, Inner Mongolia Meng Niu Dairy Industry (Group) Co.,Ltd, 011500, Hohhot, Inner Mongolia, China |
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| Abstract: | In this study, C57BL/6J male mice were fed normal chow (NC; control) or a high-fat diet (HFD) for 12 weeks, and HFD mice were supplemented with oral administration of Streptococcus thermophilus MN-ZLW-002 (HFD + MN002); n=20/group. Body weight, visceral fat, blood glucose, blood lipids and liver lipid deposition increased in the HFD group, and the composition of gut microbiota, cecum short-chain fatty acids and fecal bile acids (BAs) also changed. Oral-fed MN-002 increased the relative abundances of Ruminococcaceae, Lachnospiraceae and Streptococcaceae and improved blood glucose, liver cholesterol deposition, and serum IL-10, CCL-3 and the fecal BAs composition. In conclusion, the high-fat diet changed the composition of bile acids by shaping the gut microbiota into an obese type, leading to metabolic disturbances. Streptococcus thermophilus MN-ZLW-002 regulated gut microbiota by adjusting the composition of bile acids and improved the perturbation caused by high-fat diets. However, the effect of MN002 observed in animal experiments needs to be verified by long-term clinical trials. |
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| Keywords: | bile acids glucose metabolism gut microbiota high-fat diets Streptococcus thermophilus |
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