Skin fibroblasts from humans predisposed to colon cancer are not abnormally sensitive to DNA damaging agents |
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| Affiliation: | 1. Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;2. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Institute of Pharmaceutical Research, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;3. CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China;4. School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China;5. University of Chinese Academy of Sciences, Beijing 100049, China;6. Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada;1. TransLab, Department of Computer Science, University of Brasilia, 70910-900 Brasilia, DF, Brazil;2. Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, P.O. Box 1738, Rotterdam, The Netherlands;1. Medical Oncology Department, Centre François Baclesse, Caen, France;2. Medical Oncology Department, Centre Henri Becquerel, Rouen, France;3. Head and Neck Medical Oncology Department, Institut Gustave Roussy, Villejuif, France;4. Head and Neck Surgery Department, University Hospital, Caen, France;5. Medical Oncology Department, Centre Oscar Lambret, Lille, France;6. Medical Oncology Department, Centre Eugène Marquis, Rennes, France |
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| Abstract: | We report here that skin fibroblasts from individuals with hereditary adenomatosis of the colon and rectum (ACR), an autosomal dominant trait, were not abnormally sensitive to x-rays, UV-light or MNNG. ACR cells were also competent in restoring x-rays and UV-light induced damage of SV40 T-antigen expression following infection of these cells by the irradiated virus. We concluded, therefore, that sensitivity to x-rays, UV-light and MNNG can not be used to identify gene-carriers dominantly predisposed to colon cancer. |
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