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Glycosylated collagen |
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| Authors: | H Rosenberg J B Modrak J M Hassing W A Al-Turk S J Stohs |
| Institution: | Department of Biomedicinal Chemistry College of Pharmacy University of Nebraska Medical Center Omaha, Nebraska, 68105 USA |
| Abstract: | Collagen was separated from segments of thoracic aorta excised from normal and streptozotocin-induced diabetic rats. The extent of collagen glycosylation was determined using a colorimetric chemical procedure specific for the detection of ketoamine-linked hexoses in proteins. Diabetic rats exhibited a significant increase in glycosylated collagen as compared to normal animals. Glycosylated collagen may contribute to the development of diabetic vascular complications. |
| Keywords: | To whom correspondence should be addressed at the Department of Biomedicinal Chemistry University of Nebraska Medical Center Omaha NE 68105 |
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