A simple competitive protein-binding method for determination of progesterone in the rat plasma |
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| Authors: | Zvonimir Marić Zlatko Kniewald Stevan Milković |
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| Affiliation: | Laboratory for Experimental Medicine, University of Zagreb, Vinogradska c. 29, 41000 Zagreb, Yugoslavia |
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| Abstract: | Acetylation of the hydroxyl group in 20α-hydroxy-4--pregnen-3-one decreases the binding capacity of the molecule to transcortin to only 1% of that of progesterone. By this simple procedure it is possible to eliminate the influence of 20α-hydroxy-4-pregnen-3-one in determinations of progesterone concentrations by the competitive protein--binding method, which is highly desirable when a great number of samples are analyzed. |
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