Effect of prostaglandin F2α on pulmonary rapidly-adapting-receptors in the guinea pig |
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Authors: | Dale R. Bergren Jon M. Gustafson Donna L. Myers |
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Affiliation: | Department of Pharmacology Oral Roberts University, Tulsa, OK 74171, USA |
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Abstract: | Pulmonary rapidly-adapting-receptors (RARs) are sensory nerve endings whose afferent fibers can be recorded in the vagus nerve. RARs may play a role in reflex bronchoconstriction as seen in anaphylaxis. They can be stimulated by chemical mediators of anaphylaxis, such as prostaglandin F2α (PGF2α). PGF2α aerosol was administered to saline and bovine serum albumin (BSA)-treated guinea pigs while recording the activity of RARs. PGF2α (250 μg/ml) given for 7–13 minutes increased both tracheal pressure and nerve activity over that produced by saline exposure in untreated guinea pigs. PGF2α administered for three minutes (5–100 μg/ml) increased RAR nerve activity in a dose-related manner in the first five minutes of the experiment only in the BSA treated guinea pigs. Since changes in tracheal pressure did not show a significant dose-response relationship, the RARs responding to PGF2α seemed to be stimulated by a direct mechanism. No correlation was shown between tracheal pressure and RAR nerve activity during PGF2α treatment. Whereas, a significant correlation was found between tracheal pressure and RAR nerve activity during histamine aerosol treatment (r=0.985). Histamine aerosol (1 to 1000 μg/ml, 3 min.) increased intratracheal pressure for 3 out of 4 doses. RAR nerve activity increased significantly only at the highest dose. Therefore, a possible direct effect of PGF2α upon RARs exists while the effect of histamine seems dependent upon changes in airway pressure in the guinea pig. |
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Keywords: | Please direct reprint requests to Dale R. Bergren Department of Pharmacology School of Medicine Oral Roberts University Tulsa OK USA 74171. |
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