Eurotium (Aspergillus) repens metabolites and their biological activity |
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Authors: | M. Podojil P. Sedmera J. Vokoun V. Betina H. Baráthová Z. Ďuračková K. Horáková P. Nemec |
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Affiliation: | (1) Department of Biogenesis of Natural Products, Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4;(2) Departmènt of Technical Microbiology and Biochemistry, Faculty of Chemistry, Slovak Technical University, 880 37 Bratislava |
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Abstract: | Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities—echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 ώg/ml, caused 50 % mor7 tality inArtemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50 % growth inhibition at a concentration of 0.1 ώg/ml. |
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