Obesity-associated activation of angiotensin and endothelin in the cardiovascular system |
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| Authors: | Barton Matthias Carmona Renata Ortmann Jana Krieger José E Traupe Tobias |
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| Institution: | 1. Department of Internal Medicine, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA;2. Division of Hematology/Oncology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA;1. Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore 560 029, India;2. Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and NeuroSciences, Bangalore 560 029, India;3. Department of Biostatistics, National Institute of Mental Health and NeuroSciences, Bangalore 560 029, India |
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| Abstract: | The renin-angiotensin system (RAS) and the endothelin system have been implicated in the pathogenesis of human cardiovascular and renal diseases, and inhibition of the RAS markedly improves morbidity and survival. Obesity in humans is associated with an increased risk for the development of hypertension, atherosclerosis and focal-segmental glomerulosclerosis, however the exact mechanisms underlying these pathologies in obese individuals are not known. This article discusses the clinical importance of obesity and the current evidence for local activation of the renin-angiotensin system and its interactions with the endothelin system in obesity and the cardiovascular pathologies associated with it. |
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