Application of allyloxycarbonyl group as a protecting group to oligodeoxyribonucleotide synthesis |
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| Authors: | Y Mitsuhira S Tahara K Goto Y Hayakawa R Noyori |
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| Affiliation: | Biological Science Institute, Nippon Zeon Co. Ltd., Kanagawa, Japan. |
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| Abstract: | The allyloxycarbonyl (AOC) group, known as an efficient amino protective group in solution-phase synthesis of nucleotides, has been used for the first time in solid-phase oligonucleotide synthesis. The efficiency of the new procedure is compared with that of the conventional N-acyl protection. |
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