Relationship between an 85 kDa protein and the protective effects of Mycoplasma pneumoniae. |
| |
Authors: | M Yayoshi T Sasaki M Yoshioka |
| |
Institution: | Urawa Gakuin, Urawa, Saitama, Japan. |
| |
Abstract: | In the immunoblot analysis, sera from patients infected with Mycoplasma pneumoniae reacted with the 168 kDa (P1) and the 85 kDa proteins of virulent strain FH-P24 and P24-S1 mutant strain but not with the 85 kDa protein of P24-S11. Sera of hamsters and BALB/c mice, which had been immunized with live vaccines, were tested. In FH-P24 immunized animals, 100% or 80%, and in P24-S1, 40% of hamsters and 60% of BALB/c mice, developed antibodies against the 85 kDa protein, but antibodies were not detected in sera of P24-S11 immunized animals. The correlation between the development of antibodies to 85 kDa protein in the sera of vaccinated animals and the effects of protection by living vaccines were suggested. |
| |
Keywords: | |
|
|