Biosynthetic Pathway of Citrinin in the Filamentous Fungus Monascus ruber as Revealed by 13C Nuclear Magnetic Resonance |
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Authors: | Hassan Hajjaj, Alain Kla b , Marie O. Loret, G rard Goma, Philippe J. Blanc, Jean Fran ois |
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Affiliation: | Hassan Hajjaj, Alain Klaébé, Marie O. Loret, Gérard Goma, Philippe J. Blanc, and Jean François |
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Abstract: | Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point. |
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