A lymphoma-like neoplasm arising from hematopoietic tissue in the white shrimp, Penaeus vannamei Boone (Crustacea: Decapoda) |
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| Authors: | D V Lightner J A Brock |
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| Affiliation: | 1. Environmental Research Laboratory, University of Arizona, 2601 East Airport Drive, Tucson, Arizona 85706 USA;2. Aquaculture Development Program, Department of Land and Natural Resources, State of Hawaii, Honolulu, Hawaii 96813 USA;1. Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales 2109, Australia;2. Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA;3. School of Physics, The University of New South Wales, Sydney, New South Wales 2052, Australia;1. Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand;2. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Road, Klong 1, Klong Luang, Pathumthani 12120, Thailand;3. Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Mahidol University, Rama VI Road, Bangkok 10400, Thailand;1. Shimoda Marine Research Center, University of Tsukuba, Shimoda, Shizuoka 415-0025, Japan |
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| Abstract: | A pond-reared adult female Pacific white shrimp (Penaeus vannamei Boone, Crustacea: Decapoda) from an experimental shrimp culture facility in Hawaii was found to possess a lymphatic neoplasm. Present in this animal were bilateral hypertrophied hematopoietic nodules present ventral and lateral to the ventral nerve cord, and smaller multiple ectopic foci of similar appearing lymphoid cells in the gills, the subcutis, and other tissues. The lesions contained numerous anaplastic and hypertrophied lymphoid cells, many of which displayed bizarre mitotic figures, including polypolar metaphase figures. Numerous multinuclear giant cells present in the lesion were presumed to have originated from cells with polypolar mitotic figures. The characteristics of the cells composing these lesions, the expansive and invasive nature of the lesions, and the presence of ectopic foci of neoplastic cells support classification of this lesion as a hematopoietic sarcoma. Focal lesions of the type that are diagnostic of infections by the penaeid shrimp virus IHHN were present in the neoplastic hematopoietic tissue and other tissues of this shrimp, suggesting the possible role of viral infection in the development of neoplastic lesions in this animal. |
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