Histones and histone synthesis in sea urchin development |
| |
Authors: | J V Ruderman P R Gross |
| |
Institution: | 1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA;2. Department of Biology, University of Rochester, Rochester, New York 14627 USA |
| |
Abstract: | Histones are synthesized and become a part of the chromatin as early as the first cleavage in sea urchins. Reproducible changes in relative amounts of individual histone fractions synthesized are observed during development. A new and electrophoretically distinct very lysine rich fraction appears at hatching in Arbacia and in the early gastrula of Lytechinus. When RNA synthesis is blocked by actinomycin D, maternal mRNA alone can direct a quantitatively and qualitatively changing pattern of histone synthesis as cleavage proceeds. Inhibition of DNA synthesis by hydroxyurea reduces synthesis of histones; the arginine-rich histones are more severely affected than the lysine-rich ones. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|