Effect of fatty-acyl-CoAs on the elongation of saturated fatty acid in porcine aorta microsomes |
| |
| Authors: | K Murakami S Yoshida M Takeshita |
| |
| Institution: | Department of Biochemistry, Medical College of Oita, Japan. |
| |
| Abstract: | The microsomal elongation system from porcine aorta for longchain fatty-acyl-CoAs was investigated. Palmitoleoyl-CoA (16:1-CoA), oleoyl-CoA (18:1-CoA), and eicosenoyl-CoA (20:1-CoA) remarkably depressed the elongation activity for 16:0-CoA in aorta microsomes by 44.8, 52.4, and 43.7% of the control activity, respectively. Saturated and polyunsaturated fatty-acyl-CoAs had little effect on the 16:0-CoA elongation activity. These results indicate that monounsaturated long-chain fatty acyl-CoAs can regulate the synthesis of saturated fatty acids in the vessel walls. |
| |
| Keywords: | |
|
|
