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Immunity as a link between obesity and insulin resistance |
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| Authors: | Kalupahana Nishan S Moustaid-Moussa Naima Claycombe Kate J |
| Institution: | a Obesity Research Center, The University of Tennessee (UT), United States b Department of Physiology, Faculty of Medicine, University of Peradeniya, Sri Lanka c Department of Animal Science, The University of Tennessee (UT), United States d The University of Tennessee (UT), UT Extension Department of Family and Consumer Sciences, Knoxville, TN 37996, United States e USDA-ARS, GFHNRC, Grand Forks, ND, United States |
| Abstract: | Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review. |
| Keywords: | Obesity Insulin resistance Adipose tissue inflammation Type-2 diabetes |
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