Effects of the polysaccharide from Pholiota nameko on human cytokine network in serum |
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| Authors: | Li Haiping Liu Xiaojuan Li Yang Hua Yanjun Zhi Dexian Pang Guangchang |
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| Affiliation: | Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, PR China |
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| Abstract: | Some physico-chemical characterizations of Pholiota nameko polysaccharides (PNPS-1) were studied, including sulfate content, UV/visible and infrared spectra, also the variation of cytokine communication network in serum to clarify the pharmacological effects of PNPS-1 by determination of 39 cytokines in serum of healthy volunteers. The result proved that PNPS-1 possessed significant anti-inflammatory activity. Further, we use Microsoft Visio 2007 software to map out the cell-cell communication network diagram. The analysis to the diagram suggested that PNPS-1 could take effect on the innate and adaptive immunity and hematopoiesis of volunteers. |
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| Keywords: | EGF, epidermal growth factor FGF, fibroblast growth factors Fit, Fit-3 ligand G-CSF, granulocyte colony stimulating factor GM-CSF, granulocyte-macrophage-colony stimulating factor GRO, growth related oncogene INF, Interferon IL, interleukin IP-10, interferon inducible protein-10 M-CSF, macrophage-colony stimulating factor MCP, monocyte chemotactic protein MDC, macrophage-derived chemokine MIP, macrophage inflammatory protein sCD40L, soluble CD40 ligand TGF, transforming growth factor TNF, tumor necrosis factor VEGF, vascular endothelial cell growth factor |
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