Autophagy, nutrition and immunology |
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Authors: | Cuervo Ana Maria Macian Fernando |
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Institution: | a Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA b Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA c Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA |
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Abstract: | Turnover of cellular components in lysosomes or autophagy is an essential mechanism for cellular quality control. Added to this cleaning role, autophagy has recently been shown to participate in the dynamic interaction of cells with the surrounding environment by acting as a point of integration of extracellular cues. In this review, we focus on the relationship between autophagy and two types of environmental factors: nutrients and pathogens. We describe their direct effect on autophagy and discuss how the autophagic reaction to these stimuli allows cells to accommodate the requirements of the cellular response to stress, including those specific to the immune responses. |
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Keywords: | Aging Antigen presentation Chaperones Lipids Lysosomes Starvation T-cells |
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