Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering |
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| Authors: | Tripathi Anjali Saravanan Sekaran Pattnaik Soumitri Moorthi Ambigapathi Partridge Nicola C Selvamurugan Nagarajan |
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| Affiliation: | a Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India
b Department of Basic and Craniofacial Biology, New York University College of Dentistry, New York University, New York, USA |
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| Abstract: | The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering. |
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| Keywords: | Chitosan Nano-hydroxyapatite Copper-zinc alloy Cytotoxicity Antibacterial activity Bone |
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