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香菇C91-3菌丝发酵蛋白对S180小鼠细胞免疫功能和IFN-γ及TNF-α的作用
引用本文:曹婧,宁安红,钟民涛,黄敏. 香菇C91-3菌丝发酵蛋白对S180小鼠细胞免疫功能和IFN-γ及TNF-α的作用[J]. 中国微生态学杂志, 2013, 0(10): 1137-1138,1148
作者姓名:曹婧  宁安红  钟民涛  黄敏
作者单位:大连医科大学病原生物学实验室,辽宁大连116044
摘    要:目的观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠免疫系统的作用。方法昆明小鼠24只,S180瘤细胞荷瘤建立动物模型,随机平均分为3组:香菇C91-3菌丝发酵蛋白治疗组、环磷酰胺治疗组、生理盐水对照组。观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠NK细胞活性、淋巴细胞转化率、IFN-γ和TNF-α等免疫指标的影响。结果香菇C91-3菌丝发酵蛋白能够显著提高治疗组小鼠的NK细胞活性、淋巴细胞转化率和血清中IFN-γ和TNF-α的含量。结论香菇C91-3菌丝发酵蛋白能够显著提高荷瘤小鼠免疫系统的活性。

关 键 词:香菇C91-菌丝发酵蛋白  小鼠  免疫

The action of lentinus edodes C91-3 mycelium's fermentative protein on immune system of the mice with S180 tumor
CAO Jing,NING An-hong,ZHONG Min-tao,HUANG Min. The action of lentinus edodes C91-3 mycelium's fermentative protein on immune system of the mice with S180 tumor[J]. Chinese Journal of Microecology, 2013, 0(10): 1137-1138,1148
Authors:CAO Jing  NING An-hong  ZHONG Min-tao  HUANG Min
Affiliation:g(Dalian Medical University, Dalian 116044, China)
Abstract:Objective To observe the action of lentinus edodes C91-3 mycelium's fermentative protein ( LFP91-3) on immune systemof the mice with S180 tumor. Methods Inbred male and female Kunming mice were used to create animal mode. Twenty-four mice wererandomly divided into LFP91.3 group, cyclophosphamide group and normal sodium control group. Then NK cell activity, lymphocyte trans-formation rate, serum IFN-γ and TNF-α were observed in comparison with the control groups. Results NK cell activity, lymphocytetransformation rate, serum IFN-γ and TNF-α in the treatment group of lentinus edodes C91-3 mycelium’s fermentative protein were higherthan those in other groups. Conclusion Lentinus edodes C91-3 mycelium's fermentative protein can enhance the activity of immune systemof mice with tumor.
Keywords:Lentinus edodes C91-3 mycelium's fermentative protein  Mouse; Immunity
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