A flavonoid gossypin binds to cyclin-dependent kinase 2 |
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| Authors: | Kim Hojung Lee Eunjung Kim Jihye Jung Bora Chong Youhoon Ahn Joong-Hoon Lim Yoongho |
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| Affiliation: | Department of Bioscience and Biotechnology, BMIC, 1 Hwayang-dong, Kwangjin-Ku, Konkuk University, Seoul 143-701, Republic of Korea. |
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| Abstract: | Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments. |
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