Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure |
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| Authors: | T E Jessen K L Faarvang M Ploug |
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| Affiliation: | Department of Clinical Chemistry, Holbaek Central Hospital, Denmark. |
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| Abstract: | The primary structure of inter-alpha-trypsin inhibitor is partially elucidated, but controversy about the construction of the polypeptide backbone still exists. We present evidence suggesting that inter-alpha-trypsin inhibitor represents a novel plasma protein structure with two separate polypeptide chains covalently crosslinked only by carbohydrate (chondroitin sulphate). |
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