Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1) |
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| Authors: | Yang Quan-Sheng Ying Kang Yuan Hong-Ling Chen Jin-Zhong Meng Xian-Fang Wang Zhao Xie Yi Mao Yu-Min |
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| Institution: | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433, Shanghai, PR China. |
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| Abstract: | A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2. |
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