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Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection
Authors:Marion Rother  Erik Gonzalez  Ana Rita Teixeira da Costa  Lea Wask  Isabella Gravenstein  Matteo Pardo  Matthias Pietzke  Rajendra Kumar Gurumurthy  Jörg Angermann  Robert Laudeley  Silke Glage  Michael Meyer  Cindrilla Chumduri  Stefan Kempa  Klaus Dinkel  Anke Unger  Bert Klebl  Andreas Klos  Thomas F. Meyer
Affiliation:1. Max Planck Institute for Infection Biology, Department of Molecular Biology, Charitéplatz 1, 10117 Berlin, Germany;2. Center for Systems Biomedicine, Steinbeis Innovation, 14612 Falkensee, Germany;3. Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany;4. Institute for Applied Mathematics and Information Technologies, Italian National Research Council, 16149 Genova, Italy;5. Integrative Metabolomics and Proteomics, Institute of Medical Systems Biology, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany;6. Institute for Laboratory Animal Science, Hannover Medical School, 30625 Hannover, Germany;7. Lead Discovery Center GmbH, 44227 Dortmund, Germany
Abstract:
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  • Keywords:RNAi screen  metabolomics screen  nucleotide  Warburg effect  IMPDH  MMF
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