Molecular Classification of Coxsackie A Viruses on the Basis of the 5'-UTR: Structural and Evolutionary Aspects |
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Authors: | Nikolaos Siafakas Panayotis Markoulatos Glyn Stanway |
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Institution: | (1) Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, Athens 115 21, Greece, GR;(2) Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, Essex, England, GB |
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Abstract: | The sequences from a large part of the 5'-UTR of 21 coxsackie A virus (CAV) reference strains for which such data did not
exist in the past were obtained. Those sequences, along with the respective available sequences from the rest of the CAV reference
strains and many other enteroviruses, were compared. According to the results of this comparison, enteroviruses are classified
into two genetic clusters on the basis of 5'-UTR, and CAVs are divided into these two clusters. Specifically, it was found
that CAV1, -11, -13, -15, -17 to -22, and -24 are classified together with polioviruses and enterovirus 70, whereas the rest
of the CAVs are classified along with coxsackie B viruses, echoviruses, and the rest of the other enteroviruses. No correlation
between overall 5'-UTR identity and the currently recognized human enterovirus species was found. The phenomenon of "covariance"
in the 5'-UTR was followed for the prediction of the possible secondary structure of the 5'-UTR of the CAVs sequenced in the
present study. |
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