The Effect of Free Radicals Induced by Paraquat and Copper on the In Vitro Development of Plasmodium falciparum |
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| Authors: | Esther Marva Mordechai Chevion Jacob Golenser |
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| Affiliation: | a The Departments of Parasitology the Kuvin Centre for Tropical Diseases Cellular Biochemistry, The Hebrew University, Jerusalem, Israelb The Departments of Cellular Biochemistry, The Hebrew University, Jerusalem, Israel |
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| Abstract: | The role of transition metals in paraquat toxicity was studied in cultures of Plasmodium falciparum. We showed that addition of copper led to an enhancement of the plasmodium killing, whereas addition of chelating agents. such as desferrioxamine and diethylenetriamine pentaacetic acid markedly reduced the toxic effects. Parsitized G6PD deficient erythrocytes were more sensitive than parasitized normal eryth-rocytes to copper and to the combination of copper and paraquat. |
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| Keywords: | Malaria Paraquat transition metals oxidant stress |
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