Selenium and Cadmium Levels and Ratios in Prostates,Livers, and Kidneys of Nonsmokers and Smokers |
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Authors: | Jutta Schöpfer Gustav Drasch Gerhard N Schrauzer |
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Institution: | 1.Institut für Rechtsmedizin,Ludwig-Maximillians Universit?t,Munich,Germany;2.Biological Trace Element Research Institute,Chula Vista,USA;3.Department of Chemistry and Biochemistry,University of California,San Diego,USA |
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Abstract: | Cadmium (Cd) from cigarette smoke, environmental, and nutritional sources accumulates in the human prostate where it interacts
with selenium (Se) in a manner suggesting the formation of a 1:1 Cd–Se–protein complex. At low Cd exposures and adequate Se
status, this interaction may be beneficial as it results in the detoxification of Cd. At higher exposures, Cd may weaken or
abolish the anticarcinogenic effects of Se and increase prostate cancer risk. In some older men and especially in smokers,
Cd levels in prostates reach levels in stoichiometric excess over Se, which may be the reason why heavy smokers are at higher
risk of developing lethal forms of prostate cancer. In the liver and the kidneys, Cd accumulates as well, but in these organs,
Cd is efficiently sequestered through metallothionein formation. In the prostate, this mode of detoxification is not available
or less efficient, causing Cd to interact with Se and to increase prostate cancer risk. |
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