Identifying novel genes in <Emphasis Type="Italic">C. elegans</Emphasis> using SAGE tags |
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Authors: | Matthew J Nesbitt Donald G Moerman Nansheng Chen |
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Institution: | (1) Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada;(2) Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada |
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Abstract: | Background Despite extensive efforts devoted to predicting protein-coding genes in genome sequences, many bona fide genes have not been found and many existing gene models are not accurate in all sequenced eukaryote genomes. This situation
is partly explained by the fact that gene prediction programs have been developed based on our incomplete understanding of
gene feature information such as splicing and promoter characteristics. Additionally, full-length cDNAs of many genes and
their isoforms are hard to obtain due to their low level or rare expression. In order to obtain full-length sequences of all
protein-coding genes, alternative approaches are required. |
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Keywords: | |
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