ProbABEL package for genome-wide association analysis of imputed data |
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| Authors: | Yurii S Aulchenko Maksim V Struchalin Cornelia M van Duijn |
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| Institution: | (1) Department of Epidemiology, Erasmus MC, Postbus 2040, 3000, CA, Rotterdam, The Netherlands;(2) Institute of Cytology and Genetics SD RAS, Novosibirsk, 630090, Russia |
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| Abstract: | Background Over the last few years, genome-wide association (GWA) studies became a tool of choice for the identification of loci associated
with complex traits. Currently, imputed single nucleotide polymorphisms (SNP) data are frequently used in GWA analyzes. Correct
analysis of imputed data calls for the implementation of specific methods which take genotype imputation uncertainty into
account. |
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