银杏酮酯滴丸联合美托洛尔对冠心病不稳定型心绞痛患者心肌酶指标、氧化应激和外周血IL-33/ST2信号通路的影响

摘要 目的：观察银杏酮酯滴丸联合美托洛尔对冠心病不稳定型心绞痛（UAP）患者心肌酶指标、氧化应激和外周血白介素-33（IL-33）/生长刺激表达基因2蛋白（ST2）信号通路的影响。方法：选取我院2020年1月~2021年12月期间收治的UAP患者70例，根据随机数字表法分为对照组（美托洛尔治疗，35例）和联合组（银杏酮酯滴丸联合美托洛尔治疗，35例），对比两组疗效、心绞痛改善情况、心肌酶指标、氧化应激及外周血IL-33/ST2信号通路相关指标，记录不良反应发生情况。结果：联合组的临床总有效率（88.57%）高于对照组（68.57%），差异有统计学意义（P<0.05）。治疗1个月后，联合组的心绞痛发作次数少于对照组，心绞痛发作持续时间短于对照组（P<0.05）。治疗1个月后，联合组血清肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、心肌肌钙蛋白（cTnI）低于对照组（P<0.05）。治疗1个月后，联合组血清丙二醛（MDA）水平低于对照组，血清超氧化物歧化酶（SOD）、总抗氧化能力（T-AOC）水平高于对照组（P<0.05）。治疗1个月后，联合组IL-33、ST2信使核糖核酸（mRNA）相对表达量低于对照组（P<0.05）。两组不良反应发生率组间对比无统计学差异（P>0.05）。结论：银杏酮酯滴丸联合美托洛尔治疗UAP患者，可促进症状改善，减轻心肌损伤和氧化应激，作用机制可能与调节IL-33/ST2信号通路有关。

Effects of Ginkgo Biloba Ketone Ester Dropping Pills Combined with Metoprolol on Myocardial Enzyme Indexes, Oxidative Stress and Peripheral Blood IL-33/ST2 Signal Pathway in Patients with Unstable Angina Pectoris of Coronary Heart Disease

ABSTRACT Objective: To observe the effects of Ginkgo biloba ketone ester dropping pills combined with metoprolol on myocardial enzyme indexes, oxidative stress and peripheral blood interleukin-33 (IL-33)/growth stimulating gene 2 protein (ST2) signal pathway in patients with unstable angina pectoris (UAP). Methods: 70 patients with UAP who were treated in our hospital from January 2020 to December 2021 were selected, and they were randomly divided into control group (treated with metoprolol, 35 cases) and combined group (treated with Ginkgo biloba ketone ester dropping pills combined with metoprolol, 35 cases). The curative effects, improvement of angina pectoris, myocardial enzyme indexes, oxidative stress and peripheral blood IL-33/ST2 signal pathway related indexes were compared between the two groups, and the occurrence of adverse reactions was recorded. Results: The total clinical effective rate in the combined group (88.57%) was higher than (68.57%) in the control group, and the difference was statistically significant(P<0.05). 1 month after treatment, the frequency of angina pectoris attack in the combined group was less than that in the control group, and the duration of angina pectoris attack was shorter than that in the control group(P<0.05). 1 month after treatment, the serum creatine kinase isozyme (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK) and cardiac troponin (cTnI) in the combined group were lower than those in the control group (P<0.05). 1 month after treatment, the levels of serum malondialdehyde (MDA) in the combined group was lower than that in the control group, and the levels of serum superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were higher than those in the control group (P<0.05). 1 month after treatment, the relative expression of IL-33 and ST2 messenger RNA (mRNA) in the combined group was lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Ginkgo biloba ketone ester dropping pills combined with metoprolol in the treatment of patients with UAP can promote the improvement of symptoms, reduce myocardial injury and oxidative stress. The mechanism may be related to the regulation of IL-33/ST2 signal pathway.