lp-PLA2、RBP与冠心病病变程度相关性及其疾病诱发的危险因素分析

摘要 目的：研究脂蛋白磷脂酶A2（lp-PLA2）、视黄醇结合蛋白（RBP）与冠心病（CAD）病变程度的相关性及冠心病病变发生的危险因素。方法：以2019年12月至2021年12月在本院诊治的冠心病患者140例作为研究对象，所有患者均进行冠状动脉造影检查，并根据冠状动脉侧支循环形成情况进行分级。所有患者都给予血清lp-PLA2、RBP检测并进行相关性、危险因素分析。结果：在140例患者中，冠状动脉侧支循环未形成40例（对照组），冠状动脉侧支循环形成100例（研究组），研究组中Ⅰ级40例，Ⅱ级38例，Ⅲ级22例。研究组的血清lp-PLA2、RBP含量都高于对照组（P<0.05）；不同分级患者的血清lp-PLA2、RBP含量对比也有明显差异（P<0.05）。在冠心病患者中，Spearsman相关分析显示血清lp-PLA2、RBP含量与侧支循环形成分级存在正相关性（P<0.05）。logistic回归分析显示血清lp-PLA2、RBP含量均为影响冠心病患者侧支循环形成分级的危险因素（P<0.05）。ROC曲线分析显示血清lp-PLA2、RBP含量预测冠心病患者侧支循环分级的曲线下面积为0.891、0.805。结论：随着冠状动脉侧支循环形成，冠心病患者的血清lp-PLA2、RBP含量明显增加，lp-PLA2、RBP与侧支循环形成分级存在相关性，也是影响侧支循环分级的危险因素，也可预测侧支循环分级状况。

Correlation between lp-PLA2, RBP and The Degree of Coronary Heart Disease and The Risk Factors of Disease-induced Disease

ABSTRACT Objective: To explore and analysis the correlation between lipoprotein phospholipase A2 (lp-PLA2), retinol-binding protein (RBP) and the degree of coronary heart disease and the risk factors of disease-induced disease. Methods: 140 patients with coronary heart disease who were diagnosed and treated in our hospital from December 2019 to December 2021 were selected as the research subjects. All patients underwent coronary angiography and were graded according to the formation of coronary collateral circulation. All patients were given serum lp-PLA2, RBP detection and correlation and risk factor analysis. Results: Among the 140 patients, 40 patients had no coronary collateral circulation (matched group), 100 patients had coronary collateral circulation (research group), 40 patients had grade I, 38 had grade II, and 22 had grade III. The serum lp-PLA2 and RBP contents of the research group were higher than those of the matched group (P<0.05); the serum lp-PLA2 and RBP contents of patients with different grades were also different (P<0.05). In patients with coronary heart disease, Spearsman correlation analysis showed that serum lp-PLA2 and RBP levels were positive correlated with the grade of collateral circulation formation (P<0.05). Logistic regression analysis showed that serum lp-PLA2 and RBP levels were both risk factors for the formation of collateral circulation in patients with coronary heart disease (P<0.05). ROC curve analysis showed that the areas under the curve of serum lp-PLA2 and RBP levels for predicting collateral circulation grade in patients with coronary heart disease were 0.891 and 0.805. Conclusion: With the formation of coronary collateral circulation, the serum levels of lp-PLA2 and RBP in patients with coronary heart disease are significantly increased. Prediction of collateral circulation grading status.