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Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel |
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| Authors: | Turney B J Cheruvallath Z S Andrade M Cole D L Ravikumar V T |
| Affiliation: | Isis Pharmaceuticals, Carlsbad, CA 92008, USA. |
| Abstract: | Oligodeoxyribonucleotide phosphorothioates undergo desulfurization in presence of metal in aqueous ammonia at elevated temperatures. The extent of sulfur loss and chain cleavage have been investigated. |
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