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Primary‐like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures |
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| Authors: | Natalie Herzog Max Hansen Sebastian Miethbauer Kai‐Uwe Schmidtke Ursula Anderer Amelie Lupp Sebastian Sperling Daniel Seehofer Georg Damm Katrin Scheibner Jan‐Heiner Küpper |
| Institution: | 1. Faculty of Science, Brandenburg University of Technology Cottbus‐Senftenberg, Senftenberg, Germany;2. Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany;3. Department of General, Visceral and Transplantation Surgery, Charité University Medicine, Berlin, Germany |
| Abstract: | |
| Keywords: | biotransformation CYP450 hepatocytes in vitro drug testing spheroids xenobiotics |