Bioactive constituents from gum guggul (Commiphora wightii) |
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| Authors: | Zhu N Rafi M M DiPaola R S Xin J Chin C K Badmaev V Ghai G Rosen R T Ho C T |
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| Institution: | Department of Food Science and Center for Advanced Food Technology, Rutgers University, New Brunswick, NJ 08901, USA. |
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| Abstract: | Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. |
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