In vitro and in vivo studies on CCR10 regulation by Annexin A1 |
| |
Authors: | Rodrigues-Lisoni Flavia Cristina Mehet Devinder K Mehemet Devinder K Peitl Paulo John Christopher D da Silva Júnior Wilson Araújo Tajara Eloiza Buckingham Julia C Solito Egle |
| |
Affiliation: | Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. |
| |
Abstract: | The mode of action of annexin A1 (ANXA1) is poorly understood. By using rapid subtraction hybridization we studied the effects of human recombinant ANXA1 and the N-terminal ANXA1 peptide on gene expression in a human larynx cell line. Three genes showed strong downregulation after treatment with ANXA1. In contrast, expression of CCR10, a seven transmembrane G-protein coupled receptor for chemokine CCL27 involved in mucosal immunity, was increased. Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression. |
| |
Keywords: | Gene expression Host defence Annexin A1-null mice Epithelial cells Annexin A1 |
本文献已被 ScienceDirect PubMed 等数据库收录! |